CD8+ T-cell memory bears the transcriptional imprint of progressive differentiation

ABSTRACT: The generation of CD8+ T-cell memory is an important aim of immunization. While several distinct subsets of CD8+ T-cell memory have been described, the lineage relationships between effector (EFF), effector memory (EM) and central memory (CM) T cells remain contentious. Specifically, there is contradictory experimental evidence to support both the linear (Naive>EFF>EM>CM) and progressive differentiation (Naive>CM>EM>EFF) models. In this study, we applied a systems biology approach to examine global transcriptional relationships between the three major CD8+ T cell subsets arising endogenously as a result of vaccination with three different prime-boost vaccine regimens. Differential gene expression analysis and principle component analysis revealed that central memory cells were more closely

ORGANISM(S): Mus musculus

SUBMITTER: Peter Wilkinson 

PROVIDER: E-GEOD-42459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress