Timecourse of mCMV Infection of Bone Marrow-Derived Macrophages (BMDMs)

ABSTRACT: The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the program of gene activation in this cellular system. The even spacing and time intervals (every 30 minutes) makes this study amenable to modelling of gene networks in the system. A kinetic analysis of mCMV infection on the gene expression of murine (BALB/c) bone marrow-derived macrophages (BMDMs) over the first 12 hours, sampling every 30 minutes. Agilent mouse genome arrays were used to determine the differences in gene expression between mock and mCMV infected. The 25 samples collected for the mock infe

ORGANISM(S): Mus musculus

SUBMITTER: Nigel Binns 

PROVIDER: E-GEOD-42503 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress