Transcription profiling of human white blood cell sub-types before and after exercise

ABSTRACT: In recent years gene expression profiling with microarrays has become an important tool in genomic research. Its usefulness in diagnosis and disease classification is now well documented. In many cases routine access to tissues primarily involved in pathophysiological processes is not possible. Attempts have therefore been made to use gene expression patterns in white blood cells (WBCs) as surrogate markers. We investigated if the analysis of gene expression profiles in whole white blood cells is sufficient or if improvements in reliability and sensitivity can be obtained by the analysis of sorted subtypes of WBCs. Using Affymetrix U133A gene chips we have determined gene expression profiles in WBCs, PBMCs, and T-cells. Changes in gene expression were induced in these cells by oxygen-consu

ORGANISM(S): Homo sapiens

SUBMITTER: Sandy Mosig 

PROVIDER: E-GEOD-4251 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress