Transcription profiling of rat heart from rats exposed to Bis(2-chloroethoxy)methane to investigate heart toxicity and recovery in male fisher rats

ABSTRACT: Specific gene changes after exposure to the heart toxin, bis(2-chloroethoxy)methane, were analyzed to elucidate critical pathways associated with recovery from heart toxicity. Bis(2-chloroethoxy)methane was administered to male F344/N rats at 0, 200, 400, or 600 mg/kg by dermal exposure for up to 16 days. Heart toxicity occurred at day 2 of exposure in all three regions of the heart (atrium, ventricle, interventricular septum) and was characterized by myofiber vacuolation, necrosis, mononuclear-cell infiltration, and atrial thrombosis. Ultrastructural analysis revealed that the primary site of damage occured in the mitochondrion. Damaged mitochondria had disrupted cristae and loss of membrane structure, and distention of the myocardial sarcoplasmic reticulum. By day 5, even thou

ORGANISM(S): Rattus norvegicus

SUBMITTER: Joel Parker 

PROVIDER: E-GEOD-4254 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress