Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Hancock
PROVIDER: E-GEOD-42573 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20140620 6
Dendritic cells (DCs) are critical for regulating CD4 and CD8 T cell immunity, controlling Th1, Th2, and Th17 commitment, generating inducible Tregs, and mediating tolerance. It is believed that distinct DC subsets have evolved to control these different immune outcomes. However, how DC subsets mount different responses to inflammatory and/or tolerogenic signals in order to accomplish their divergent functions remains unclear. Lipopolysaccharide (LPS) provides an excellent model for investigatin ...[more]