Effect of furfural on the Clostridium beijerinckii NCIMB 8052 transcriptome

ABSTRACT: Furfural is the prevalent microbial inhibitor generated during pretreatment and hydrolysis of lignocellulosic biomass to monomeric sugars, but the molecular response of Clostridium beijerinckii NCIMB 8052 to this compound is unknown. To discern the effect of furfural on C. beijerinckii and to gain insights into the molecular mechanisms of action and detoxification, we studied the physiological changes of furfural-stressed cultures during acetone-butanol-ethanol (ABE) fermentation, and profiled differentially expressed genes by genome-wide transcriptional analysis. C. beijerinckii exposed to furfural stress during the acidogenic growth phase produced 13% more ABE than the unstressed control. The growth and ABE by C. beijerinckii ceased following exposure to furfural stress during the solve

ORGANISM(S): Clostridium beijerinckii NCIMB 8052

SUBMITTER: Yan Zhang 

PROVIDER: E-GEOD-42597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress