Escape from Immunosurveillance in Pancreatic Cancer is Mediated by the Stromal Cell Expressing Fibroblast Activation Protein-Alpha

ABSTRACT: This study sought the basis for the failure of immunosurveillance in pancreatic ductal adenocarcinoma (PDA). The FAP+ cell was shown to be immunosuppressive in a spontaneous PDA model. Bioinformatic analyses show it to be identical to the Carcinoma-associated fibroblast (CAF). FAP+ cells were sorted from pancreatic ductal adenocarcinoma. Cells were isolated in duplicate experiments and these were analysed separately. These were compared separately to previously published publicly available CD4+ T-cell subset data (C57BL/6 mice and Foxp3-RFP mice (Line 8374) GEO accession GSE20898), and previously published FAP+ cell datasets (transgenic albino (Tyr-/-) C57BL/6 mouse, GEO accession GSE39438).

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Deonarine 

PROVIDER: E-GEOD-42605 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress