MiRNA profiling of repeat kidney biopsies in Lupus Nephritis

ABSTRACT: We aimed to identify miRNA biomarkers of renal injury in kidney biopsies from patients with lupus nephritis. MiRNA profiles of 8 patients were analyzed for correlation with various clinical features including Progression, Activity, Chronicity, and Time to Kidney Failure. MicroRNAs (miRs) are promising biomarkers and are involved in pathogenesis of kidney diseases. We aimed to identify miR biomarkers of renal injury in kidney biopsies from patients with lupus nephritis and study their potential role in renal fibrosis. miR-150 was significantly increased in kidneys with high chronicity compared to low chronicity and it correlated positively with chronicity index scores and renal collagen I expression. In kidneys with high chronicity, miR-150 was found predominantly in proximal tubular cells

ORGANISM(S): Homo sapiens

SUBMITTER: Ilias Alevizos 

PROVIDER: E-GEOD-42648 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress