Quiescent innate response to infective filariae by human Langerhans’ cells suggests a strategy of immune evasion

ABSTRACT: Filarial infection is initiated by mosquito-derived, third-stage larvae (L3) deposited on the skin that transits through the epidermis containing Langerhans' cells (LC) and keratinocytes (KC), among other cells. This earliest interaction between L3 and the LC likely conditions the priming of the immune system to the parasite. To determine the nature of this interaction, human LC (Langerin+, E-cadherin+, CD1a+) were generated in vitro and exposed to live L3. LC exposed to live L3 for 48 h showed no alterations in cell surface markers CD14, CD86, CD83, CD207, E-cadherin, CD80, CD40, and HLA-DR or in mRNA expression of inflammation-associated genes such as IL-18, IL-18BP, and caspase 1. In contrast to L3, live tachyzoites of Toxoplasma gondii, an intracellular parasite, induced production of

ORGANISM(S): Homo sapiens

SUBMITTER: Roshanak Semnani 

PROVIDER: E-GEOD-42694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress