IgG antibody profiling of Leptospira interrogans serovar Copenhageni in infected and non-infected subjects using protein microarray

ABSTRACT: Leptospirosis is the most widespread zoonotic disease in the world. The lack of an adequate laboratory test is a major barrier for the diagnosis, especially during the early stages of illness, when antibiotic therapy is most effective. Therefore, there is a critical need for an efficient diagnostic test for this life threatening disease. In order to identify new targets that could be used as diagnostic makers for leptopirosis, we constructed a protein microarray chip comprising 61% of Leptospira interrogans proteome and investigated the IgG response against leptospiral antigens from 274 individuals, including 80 acute-, 80 convalescent-phase patients and 114 healthy control subjects from regions with endemic, high endemic and no endemic transmission of leptospirosis. A nitrocellulose line

ORGANISM(S): Homo sapiens

SUBMITTER: Carolina Lessa Aquino 

PROVIDER: E-GEOD-42720 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress