Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms (MPN)

ABSTRACT: Even though mutations in epigenetic regulators frequently occur in myeloproliferative neoplasms, their effects on the epigenome have not been well studied. Furthermore, even though primary myelofibrosis (PMF) has a markedly worse prognosis compared to essential thrombocytosis (ET) or polycythemia vera (PV), the molecular distinctions between these subgroups are not well elucidated. We performed the HELP (HpaII tiny fragment enriched by LM-PCR) assay to study genome-wide methylation in PV, ET and PMF samples compared with healthy controls. We determined that PV and ET are characterized by aberrant promoter hypermethylation while PMF is an epigenetically distinct subgroup characterized by both aberrant hyper and hypomethylation. Aberrant hypomethylation in PMF was seen to occur in non CpG is

ORGANISM(S): Homo sapiens

SUBMITTER: Yiting Yu 

PROVIDER: E-GEOD-42721 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress