Comparison of the genome-wide DNA methylation profiles between fast-growing and slow-growing broilers

ABSTRACT: Chicken growth traits are important in poultry production, however, little is known for its regulatory mechanism at epigenetic level. Therefore, this study aims to compare DNA methylation profiles between fast- and slow-growing broilers in order to identify candidate genes underlying chicken growth. Methylated DNA immunoprecipitation-sequencing (MeDIP-seq) was used to investigate the genome-wide DNA methylation pattern in high and low tails of Recessive White Rock (WRRh, WRRl) and that of Xinhua Chickens (XHh, XHl). The results showed that the average of methylation density was the lowest in CGIs followed by promoters. Within the gene body, the methylation density of introns was higher than UTRs and exons. Moreover, different methylation levels were observed in different repeat types with

ORGANISM(S): Gallus gallus

SUBMITTER: Xinzheng Jia 

PROVIDER: E-GEOD-42751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress