Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrea Zangrando
PROVIDER: E-GEOD-42765 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Brandimarte Lucia L Pierini Valentina V Di Giacomo Danika D Borga Chiara C Nozza Filomena F Gorello Paolo P Giordan Marco M Cazzaniga Giovanni G Te Kronnie Geertruy G Te Kronnie Geertruy G La Starza Roberta R Mecucci Cristina C
Blood 20130514 25
The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent 11q23 and 11q14 chromosome translocations. Deep sequencing recently identified NAP1L1/12q21 as another MLLT10 partner in T-cell acute lymphoblastic leukemia (T-ALL). In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. Gene expression profile signatures of the HNRNPH1- and DDX3X-MLLT10 fusions ...[more]