Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

ABSTRACT: The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphate (DSS) to mimic the relapsing nature of the disease. We used whole gene expression arrays to study differences in colonic gene expression levels between acute and more chronic DSS colitis, Acute and chronic relapsing colonic inflammation was induced in C57BL6 female mice using several cycles of exposure to DSS in drinking water, followed by recovery phases. Total RNA, extracted from snap frozen colon from five mice per condition was used to analyze mRNA expression via Affymetrix Mouse Gene 1.0 ST arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Ingrid Arijs 

PROVIDER: E-GEOD-42768 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Unique gene expression and MR T2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease.

Breynaert Christine C   Dresselaers Tom T   Perrier Clémentine C   Arijs Ingrid I   Cremer Jonathan J   Van Lommel Leentje L   Van Steen Kristel K   Ferrante Marc M   Schuit Frans F   Vermeire Séverine S   Rutgeerts Paul P   Himmelreich Uwe U   Ceuppens Jan L JL   Geboes Karel K   Van Assche Gert G  

PloS one 20130723 7

<h4>Introduction</h4>Chronically relapsing inflammation, tissue remodeling and fibrosis are hallmarks of inflammatory bowel diseases. The aim of this study was to investigate changes in connective tissue in a chronic murine model resulting from repeated cycles of dextran sodium sulphate (DSS) ingestion, to mimic the relapsing nature of the human disease.<h4>Materials and methods</h4>C57BL/6 mice were exposed to DSS in drinking water for 1 week, followed by a recovery phase of 2 weeks. This cycle  ...[more]

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