Gene expression changes resulting from attenuation of Dicer activity

ABSTRACT: Despite smaller primary tumor burdens, Pten-/-Dicer-/+ mice develop seminal vesicle obstruction at high penetrance by 32 weeks, which is in sharp contrast to that observed in Pten-/- mice. This phenomenon implies that tumors in Pten-/-Dicer-/+ mice are more locally invasive. To corroborate this invasive phenotype, we examined global changes in gene expression using Agilent 44k whole genome expression microarrays. A total of 544 genes were statistically significantly altered by at least 1.4 fold in either Pten-/-Dicer-/+ or Pten-/-Dicer-/- mice, or both mice, as compared with Pten-/- mice. Approximately 22% genes were altered in the same trend in both Pten-/-Dicer-/+ and Pten-/-Dicer-/- mice, while 70% genes were only significantly affected in Pten-/-Dicer-/- mice. Very few genes were diffe

ORGANISM(S): Mus musculus

SUBMITTER: Chad Creighton 

PROVIDER: E-GEOD-42820 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress