Stem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells

ABSTRACT: Gastric cancer is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with H. pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric tumors. However, the molecular mechanisms involved in gastric carcinogenesis are still not fully understood, making it difficult to design targeted therapeutic approaches. Aberrant expression of the specific gastric differentiation marker Sox2 (sry-related HMG box 2) has been observed in stomach cancer. However, the role of Sox2 in gastric tumors has not been well established to date. To elucidate the role of Sox2 in gastric tumorigenesis, Sox2 transcriptional activity was blocked in AZ521 cells

ORGANISM(S): Homo sapiens

SUBMITTER: Stefan Krebs 

PROVIDER: E-GEOD-42937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress