Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The effect of transcription factor AtfA on gene expression


ABSTRACT: We report the effect of the deletion of novel RNA polymerase binding protein AtfA on genome-wide transcription in Acinetobacter baylyi ADP1. Compared the transcription profile of wt vs atfA knockout in Acinetobacter baylyi ADP1 using RNA-seq.

ORGANISM(S): Acinetobacter sp. ADP1

SUBMITTER: Peter Lewis 

PROVIDER: E-GEOD-42973 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

AtfA, a new factor in global regulation of transcription in Acinetobacter spp.

Withers Ryan R   Doherty Geoff P GP   Jordan Matthew M   Yang Xiao X   Dixon Nicholas E NE   Lewis Peter J PJ  

Molecular microbiology 20140731 6


Acinetobacter species are widely distributed bacteria in the environment, and have recently gained notoriety as opportunistic nosocomial pathogens. Here we characterize a novel RNA polymerase-interacting protein named acidic transcription factor A, AtfA. It is small and highly acidic, and is widely distributed throughout the γ proteobacteria, including other significant pathogens in the genera Moraxella, Pseudomonas, Legionella and Vibrio. In the model species A. baylyi ADP1, deletion of atfA si  ...[more]

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