Gene expression profile of extraskeletal myxoid chondrosarcoma.

ABSTRACT: Abstract: Extraskeletal myxoid chondrosarcoma (EMC) is a soft tissue tumour that occurs primarily in the extremities and is characterized by a balanced translocation most commonly involving t(9;22) (q22;q12). The morphological spectrum of EMC is broad and thus a diagnosis based on histology alone can be difficult. Currently, no systemic therapy exists that improves survival in patients with EMC. In the present study, gene expression profiling has been performed to discover new diagnostic markers and potential therapeutic targets for this tumour type. Global gene expression profiling of ten EMCs and 26 other sarcomas using 42,000 spot cDNA microarrays revealed that the cases of EMC were closely related to each other and distinct from the other tumours profiled. Significance analysis of micr

ORGANISM(S): Homo sapiens

SUBMITTER: Matt Van De Rijn 

PROVIDER: E-GEOD-4303 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress