Determination of stromal signatures in breast carcinoma

ABSTRACT: Abstract: Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumor (SFT) and desmoid-type fibromatosis (DTF), by DNA microarray analysis and found that they have very different expression profiles, including significant differences in their patterns of expression of extracellular matrix genes and growth factors. Using immunohistochemistry and in situ hybridization on a tissue microarray, we found that genes specific for these two tumors have mutually specific expression in the stroma of nonneoplastic tissues. We defined a set of 7

ORGANISM(S): Homo sapiens

SUBMITTER: Matt Van De Rijn 

PROVIDER: E-GEOD-4305 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress