Changes in Mouse Uterine Transcriptome in Estrus and Proestrus

ABSTRACT: The potential for xenoestrogens and other environmental chemicals to alter female reproductive function calls for the study of their affects on endogenous hormone-regulated gene expression pathways during uterine tissue remodeling which occurs as part of the menstrual/estrus cycle. However, our knowledge of these pathways is limited. Here, we characterize changes in the CD-1 mouse uterine transcriptome during proestrus and estrus, which are regulated by estrogen and progesterone in preparation of the uterus for pregnancy. Mice were staged beginning at 6 wk of age and uterine horns were harvested after monitoring two estrus cycles. Microarray analysis identified 2,429 genes differentially expressed in estrus compared to proestrus, indicating that the mouse uterus undergoes remarkable remod

ORGANISM(S): Mus musculus

SUBMITTER: David Waxman 

PROVIDER: E-GEOD-43064 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress