ERβ activation by genistein promotes metastatic progression in prostate cancer

ABSTRACT: Androgen signalling through the androgen receptor (AR) plays a critical role in prostate cancer (PCa) initiation and progression. Estrogen and the estrogen receptor, in synergy with androgen, are essential for cell growth of the normal and malignant prostate. However, the exact role that estrogen plays in prostate carcinogenesis, and the precise mechanisms involved, remain unclear. We have previously demonstrated the metastasis-promoting effect of an estrogen receptor Beta (ERβ) agonist (genistein) and the inhibitory action of an anti-estrogen (ICI 182, 780) in patient-derived PCa xenograft models mimicking localized and metastatic disease. In this study, we compared the gene expression profiles of treated and untreated PCa xenografts using microarrays to identify a unique set of genes t

ORGANISM(S): Homo sapiens

SUBMITTER: Hisae Nakamura 

PROVIDER: E-GEOD-43146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress