MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [mRNA]

ABSTRACT: MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, e.g. T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of IL-21 in ITP. Thus, regulated microRNA were signific

ORGANISM(S): Homo sapiens

SUBMITTER: Intawat Nookaew 

PROVIDER: E-GEOD-43177 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress