The Intracellular Life of Mycobacterium avium subsp. paratuberculosis During Macrophage Stress: A Key Role for the Alternative Sigma Factor, SigH

ABSTRACT: Mycobacterium avium subspecies paratuberculosis (a.k.a. M. paratuberculosis) causes JohneM-bM-^@M-^Ys disease, an enteric infection in cattle and other ruminants, greatly afflicting the dairy industry worldwide. Once inside the cell, M. paratuberculosis is known to survive harsh microenvironments, especially those inside activated macrophages. To improve our understanding of M. paratuberculosis pathogenesis, we examined the phagosome maturation associated with transcriptional responses of M. paratuberculosis during macrophage infection. Monitoring cellular markers, only live M. paratuberculosis bacilli were able to prevent phagosome maturation and reduce its acidification. On the transcriptional level, over 300 of M. paratuberculosis genes were significantly, differentially regulated i

ORGANISM(S): Mycobacterium avium subsp. paratuberculosis K-10

SUBMITTER: Pallab Ghosh 

PROVIDER: E-GEOD-43182 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress