Gene expression profile changes in PKC-inhibitor-pretreated HT1080 cells cells after TLR3 stimulation

ABSTRACT: TLR3 stimulation by extracellular dsRNA (e.g. polyIC) induces expression of numerous genes. The inhibition of PKC by Go6976 prior to TLR3 stimulation leads to an ablation of expression of IRF-3-dependent genes. Total RNA extracted from HT1080 cells with or without 1 h pretreatment with 5 uM Go6976, after 6 h of treatment with dsRNA (polyIC), compared to untreated controls

ORGANISM(S): Homo sapiens

SUBMITTER: Ganes Sen 

PROVIDER: E-GEOD-43217 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress