Transcription profiling of mouse ovaries from FORKO mutants animals

ABSTRACT: To understand consequences of loss of FSH receptor, we used genetically altered mouse mutants with deletion of this receptor. Follitropin Receptor Knockout (FORKO) mice present various developmental and age-dependent abnormalities such as infertility, senescence and increased tumor incidences in addition to other phenotypes. To explore why the atrophic ovaries of FORKO mice develop ovarian anomalies later in life, we used expression profiling studies to gain a more comprehensive view of genes that are misregulated. Experiment Overall Design: Mice were housed under controlled temperature and constant light (12 h of light, 12 h of darkness), with food and water provided ad libitum. The female mice used in this experiment were derived by breeding heterozygotes of the 129T2 svEmsJ background.

ORGANISM(S): Mus musculus

SUBMITTER: JAYAPRAKASH ARAVINDAKSHAN 

PROVIDER: E-GEOD-4323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress