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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Sox7 and Sox17

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Irene Aksoy

PROVIDER: E-GEOD-43234 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.

Aksoy Irene I Jauch Ralf R Chen Jiaxuan J Dyla Mateusz M Divakar Ushashree U Bogu Gireesh K GK Teo Roy R Leng Ng Calista Keow CK Herath Wishva W Lili Sun S Hutchins Andrew P AP Robson Paul P Kolatkar Prasanna R PR Stanton Lawrence W LW

The EMBO journal 20130308 7

How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We show that Sox17 partners with Oct4 and binds to a unique 'compressed' Sox/Oct motif that earmarks endodermal genes. This is in contrast to the pluripotent state where Oct4 selectively partners with Sox ...[more]

PMID: 23474895

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Gene expression analysis of F9 cells double knock-down for Sox7 and Sox17

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2013-04-23 | E-GEOD-43232 | biostudies-arrayexpress

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Sox7 and Sox17

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-04-23 | GSE43234 | GEO

Genome wide expression analysis of Ctbp2 knock down mouse F9 cells

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Project description: Not available

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Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics [ChIP-seq]

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2011-10-10 | E-GEOD-30539 | biostudies-arrayexpress

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Genome-wide maps of Sox/Oct partnerships pluripotent and lineage-committed cells

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HUVEC gene profile after Sox7/Sox17 siRNA silencing

Project description:To find out the target of transcription factor Sox7 and Sox17, DNA microarray analysis was performed with RNA from Sox7 and Sox17 knockdown HUVECs.

2016-11-23 | GSE75380 | GEO

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