Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals (MeDIP-Seq)

ABSTRACT: The global prevalence of type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal T2D on metabolism of offspring have been well established, the exact molecular and mechanistic basis that mediates these impacts remains largely unclear. Here we show that paternal T2D increases the susceptibility to diabetes in offspring through the gametic epigenetic alterations. Paternal T2D led to glucose intolerance and insulin resistance in offspring. Relative to controls, offspring of T2D fathers exhibited altered gene expression patterns in the pancreatic islets, with downregulation of several genes involved in glucose metabolism and insulin signaling pathway. Epigenomic profiling of offspring

ORGANISM(S): Mus musculus

SUBMITTER: yanchang wei 

PROVIDER: E-GEOD-43238 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress