A differential polarization of Th1, Th2 and Treg immune response determines resistance and susceptibility of sheep breeds to Teladorsagia circumcincta infection

ABSTRACT: Gastrointestinal nematode (GIN) is a major economic and health concern is sheep farming. Sheep breeds such as Texel are relatively resistant to GIN than the Suffolk. With the objective to understand the underlying genetic mechanism of resistance and susceptibility at the transcriptomic level, two groups of animal from both the breed were artificially (orally) infected with 30,000 L3 larvae of prominent GIN Teladorsagia circumcincta. Subgroups of animals from each breed were slaughtered on day 0, 3, 7, 14 and 21 of post infection (p.i.). Transcriptomic profiling of abomasal lymph node was performed using RNA-seq. The perturbations in gene expression profiles in both the breeds were evident and Texel showed a more tightly regulated immune response than the Suffolk. The number of differentia

ORGANISM(S): Ovis aries

SUBMITTER: Albin Ahmed 

PROVIDER: E-GEOD-43241 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress