Molecular analysis of precursor lesions in familial pancreatic cancer

ABSTRACT: Background: With less than a 5% survival rate pancreatic adenocarcinoma (PDAC) is almost uniformly lethal. In order to make a significant impact on survival of patients with this malignancy, it is necessary to diagnose the disease early, when curative surgery is still possible. Detailed knowledge of the natural history of the disease and molecular events leading to its progression is therefore critical. Methods and Findings: We have analysed the precursor lesions, PanINs, from prophylactic pancreatectomy specimens of patients from four different kindreds with high risk of familial pancreatic cancer who were treated for histologically proven PanIN-2/3. Thus, the material was procured before pancreatic cancer has developed, rather than from PanINs in a tissue field that already contains canc

ORGANISM(S): Homo sapiens

SUBMITTER: Claude Chelala 

PROVIDER: E-GEOD-43288 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress