InVERT molding for scalable control of tissue micro-architecture

ABSTRACT: Complex tissues contain multiple cell types that are hierarchically organized within morphologically and functionally distinct compartments. Construction of engineered tissues with optimized tissue architecture has been limited by tissue fabrication techniques, which do not enable versatile microscale organization of multiple cell types in tissues of size adequate for physiologic studies and tissue therapies. Here, we present an ‘Intaglio-Void/Embed-Relief Topographic (InVERT) molding’ method for microscale organization of many cell types, including induced pluripotent stem cell (iPS)-derived progeny, within a variety of synthetic and natural extracellular matrices and across tissues of sizes appropriate for in vitro, pre-clinical, and clinical biologic studies. We demonstrate that compart

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Whittaker 

PROVIDER: E-GEOD-43309 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress