Transcriptional Profiling of Mouse Uterus at Pre-implantation Stage under VEGF Repression

ABSTRACT: In this study, a genetically repressed VEGF mouse model was used to analyze uterus transcriptome at G2.5 (gestation day 2.5) by Solexa/ Illumina’s digital gene expression (DGE) system. 831 uterus-specific and 2398 VEGF regulated genes were identified. Gene ontology analysis indicated that genes actively involved in uterus development were members of collagen biosynthesis, cell proliferation and cell apoptosis. Uterus-specific genes were enriched in activities of phosphatidyl inositol phosphate kinase, histone H3-K36 demethylation and protein acetylation. Among VEGF regulated genes, up-regulated genes were associated with RNA polymerase III activity while down-regulated genes were strongly associated with muscle development.Comparable numbers of antisense RNA transcripts were also identifie

ORGANISM(S): Mus musculus

SUBMITTER: zhong p 

PROVIDER: E-GEOD-43351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress