Striatal molecular signature of subchronic subthalamic nucleus high frequency stimulation in parkinsonian rat

ABSTRACT: This study addresses the molecular mechanisms underlying the action of subthalamic nucleus high frequency stimulation (STN-HFS) in the treatment of ParkinsonM-bM-^@M-^Ys disease and its interaction with levoDOPA (L-DOPA), focusing on the striatum. The objectives were 1) to identify the molecular signature of STN-HFS action at striatal level, associated with its efficient antiparkinsonian action, and 2) to investigate the molecular substrates of the interaction between the two treatments in order to evidence possible genes involved in dyskinesia. Striatal gene expression profile was assessed in rats with nigral DOPAmine neuron lesion, either treated or not, using agilent microarrays and qPCR verification. The treatments consisted in anti-akinetic STN-HFS (5 days), chronic L-DOPA treatment

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sylviane Lortet 

PROVIDER: E-GEOD-43375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress