Cell wall-deficient Mycoplasma hominis represses biofilm formation of uropathogenic Escherichia coli.

ABSTRACT: The features of Mycoplasma in human organ such lung and urinary tract are enigmatic. Here, the role of M. hominis in regard to biofilm formation of uropathogenic Escherichia coli (UPEC) strain CFT073 was investigated. Although M. hominis were inferred to not impact on UPEC bacterial fitness including growth and productions of signaling molecules as autoinducer-2 (AI-2) and indole, we found that the presence of M. hominis dramatically decreased biofilm formation of UPEC CFT073 as well as slightly repressed attachment and cytotoxicity of that. Importantly, this activity was observed on UPEC strain specifically, not enterohemorrhagic E. coli (EHEC) strain that exists on intestine. Whole-transcriptome profiling and quantitative real-time polymerase chain reaction (qRT-PCR) analysis revealed

ORGANISM(S): Escherichia coli CFT073

SUBMITTER: Younghoon Kim 

PROVIDER: E-GEOD-43376 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress