Gene Expression profiles of colon from Hif-2αF/F, Hif-2αlΔIE treated with DSS

ABSTRACT: To investigate the detailed molecular mechanisms for the regulatory role of HIF-2α in experimental colitis, microarray gene expression analysis was performed on colon RNA isolated from 6- to 8-week-old Hif-2αF/F, Hif-2αlΔIE mice treated with 3%DSS for 3 days. Background & Aims: Hypoxic inflammation is characterized by decreased oxygen tension in inflammatory foci, and is a notable feature in inflammatory bowel disease (IBD). Hypoxic response is mediated by transcription factors hypoxia-inducible factor (HIF)-1α and HIF-2α, both of which are highly induced in IBD. HIF-1α is a protective factor that limits intestinal barrier dysfunction during inflammation. However, the role of HIF-2α has not been assessed in hypoxic inflammation and IBD. Methods: A hypoxia reporter mouse model was used to

ORGANISM(S): Mus musculus

SUBMITTER: XIANG XUE 

PROVIDER: E-GEOD-43416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress