DNA methylation profiles in the uterus during early pregnancy

ABSTRACT: Co-ordinated regulation of endometrial gene expression is essential for successful pregnancy establishment. A non-receptive uterine environment may be a key contributor to pregnancy loss, as the majority of pregnancy losses occur prior to embryo implantation. DNA methylation has been highlighted as a potential contributor in regulating early pregnancy events in the uterus. It was hypothesized that DNA methylation regulates expression of key genes in the uterus during pregnancy. To gain support for this hypothesis the correlation between DNA methylation and gene expression was tested. Endometrial samples from fertile and sub-fertile dairy cow strains were obtained at day 17 of pregnancy or the reproductive cycle. Microarrays were used to characterize genome-wide DNA methylation profiles

ORGANISM(S): Bos taurus

SUBMITTER: Caroline Walker 

PROVIDER: E-GEOD-43501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress