Phenotypic changes in PMN from production to site of infecction

ABSTRACT: Neutrophils, key cells of the innate immune system, are responsible for preventing bacterial infections. It has recently been established that neutrophils are capable of complex changes in gene expression during inflammation. The concept that neutrophils merely respond to external signals has been replaced by the concept that activated neutrophils can secrete a variety of cytokines and also have an active regulatory role in angiogenesis and tumoural fate. Currently, neutrophil research relies mostly in animal models that reproduce human physiology and pathology. Although, in many respects, there is a conservation of functions in mice and humans, little is known about genomic conservation of neutrophils between mice and humans. We hypothesize that neutrophils are transcriptionally active

ORGANISM(S): Mus musculus

SUBMITTER: Flavia Lakschevitz 

PROVIDER: E-GEOD-43513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress