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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling of human medulloblastoma cell line ONS76 upon siRNA-mediated knockdown of KDM5A/LSD1

ABSTRACT: KDM5A/LSD1 is an important epigenetic regulator in medulloblastoma, the most frequent brain tumor of childhood. Here, the response of ONS76 medulloblastoma cells upon siRNA-mediated knockdown of KDM5A is analysed. The expression profile of ONS76 cells upon KDM5A knockdown was compared to mock control. Both conditions were run in triplicate.

ORGANISM(S): Homo sapiens

SUBMITTER: Alexander Schramm

PROVIDER: E-GEOD-43552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma.

Pajtler Kristian W KW Weingarten Christina C Thor Theresa T Künkele Annette A Heukamp Lukas C LC Büttner Reinhard R Suzuki Takayoshi T Miyata Naoki N Grotzer Michael M Rieb Anja A Sprüssel Annika A Eggert Angelika A Schramm Alexander A Schulte Johannes H JH

Acta neuropathologica communications 20130529

<h4>Background</h4>Medulloblastoma is a leading cause of childhood cancer-related deaths. Current aggressive treatments frequently lead to cognitive and neurological disabilities in survivors. Novel targeted therapies are required to improve outcome in high-risk medulloblastoma patients and quality of life of survivors. Targeting enzymes controlling epigenetic alterations is a promising approach recently bolstered by the identification of mutations in histone demethylating enzymes in medulloblas ...[more]

PMID: 24252778

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Expression profiling of human medulloblastoma cell line ONS76 upon siRNA-mediated knockdown of KDM5A/LSD1

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2013-08-01 | GSE43552 | GEO

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Project description:KDM5A regulates p53 expression by modulating the expression of a subgroup of translation iniation genes.

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