RNA-mediated paternal heredity of diet induced type II diabetes and obesity.

ABSTRACT: Epidemiological surveys first indicated that obesity and type II diabetes generated by lipid rich diets may be efficiently inherited, both paternally and maternally. This apparent exception to the fundamental law of non heritability of acquired characters was more recently documented in laboratory organisms but the transgenerational signal remained a matter of speculation. Here we show that experimental transfer to healthy one-cell embryos of testis RNA prepared from males raised on high-fat-diet (HFD) results in the development of obesity and diabetes in the adult. Body weight, fasting glucose levels, response to insulin, glucose tolerance, RNA levels of leptin and stearoyl-CoA desaturase were all affected in mice born after RNA microinjection to the same extent as in the progenitors and

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lebrigand 

PROVIDER: E-GEOD-43555 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress