Reprogramming of human fibroblasts toward a cardiac fate

ABSTRACT: Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression of cardiac transcription factors or microRNAs has recently been demonstrated. The potential clinical applicability of these findings is based on the minimal regenerative potential of the adult human heart and the limited availability of human heart tissue. An initial, but mandatory step toward clinical application of this approach is to establish conditions for conversion of adult human fibroblasts to a cardiac phenotype. Toward this goal, we sought to determine the optimal combination of factors necessary and sufficient for direct myocardial reprogramming of human fibroblasts. Here we show that four human cardiac transcription factors, including Gata4, Hand2, Tbx5, and myocardin, and two microRNAs, m

ORGANISM(S): Homo sapiens

SUBMITTER: young-jae Nam 

PROVIDER: E-GEOD-43588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress