Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells [DEG.ABC]

ABSTRACT: Pentavalent vanadium compounds induce intracellular changes in vitro that are consistent with those of other carcinogenic substances, including alteration of transcription factor levels, promotion of oxidative stress, inflammation, DNA damage, stimulation of mitogenic signals, and suppression of apoptosis. While there is no clear evidence that vanadium compounds cause cancer in humans, vanadium pentoxide causes lung cancer in rodents after long-term inhalation exposures and in turn IARC has categorized it as a group 2B possible human carcinogen. The goal of this study was to investigate the carcinogenicity of NaVO3 in the human immortalized bronchial epithelial cell line, Beas-2B. Cells were treated with 10 M-BM-5M NaVO3 for 5 weeks, with or without recovery time, followed by gene express

ORGANISM(S): Homo sapiens

SUBMITTER: Lisa Passantino 

PROVIDER: E-GEOD-43593 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress