Cell cycle dependence of neuroprogenitor fate determination regulated by Trrap-mediated histone acetylation

ABSTRACT: Epigenetic control of neural stem/progenitor cell fate is fundamental to achieve a fully brain architecture. Two intrinsic programs regulate neurogenesis, one by epigenetic-mediated gene transcription and another by cell cycle control. Whether and how these two are coordinated to determine temporally and spatially neural development remains unknown. Here we show that deletion of Trrap (Transcription translation associated protein), an essential cofactor for HAT (histone acetyltransferase), leads to severe brain atrophy due to a combination of cell death and a blockade of neuron production. Specifically, Trrap deletion forces differentiation of apical progenitor (AP) fate into basal progenitors (BP) and neurons thereby limiting the total neurogenic production. Despite TrrapM-bM-^@M-^Ys gene

ORGANISM(S): Mus musculus

SUBMITTER: Zechen Chong 

PROVIDER: E-GEOD-43650 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress