Transcriptomic Dynamics of Human Macrophage Response to Leishmania major infection

ABSTRACT: Leishmania (L.) are obligated intracellular protozoan parasites that develop electively in macrophages. These cells that are acting as a safe shelter for the pathogens but also as their ultimate killer, making them the alpha and the omega during leishmaniasis diseases. Macrophages are able to secrete a remarkably diverse set of regulators known to influence the physiological functions and differentiation of neighboring cells to trigger an adaptive immune response of protective Th1-type cells, whereas parasites have developed a wide range of mechanisms to circumvent the host’s immune responses. Most of our understanding of this host-parasite conflict, in the context of macrophage invasion by L. major metacyclic promastigotes, has been gleaned from studies investigating the macrophage resp

ORGANISM(S): Homo sapiens

SUBMITTER: Dhafer Laouini 

PROVIDER: E-GEOD-43661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress