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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC), from wild-type, IFNAR1-/-, IL28Ra-/- and IFNAR1-/- IL28Ra-/- double ko

ABSTRACT: We used microarrays to detail the global programme of gene expression in response to Influenza A (PR8) infection Fully differentiated MTEC cells were infected with PR8 (moi: 0.3) or mock infected and RNA was collected at 24 hours post infection

ORGANISM(S): Mus musculus

SUBMITTER: Stefania Crotta

PROVIDER: E-GEOD-43708 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC)

Project description:We used microarrays to detail the global programme of gene expression in response to Influenza A (PR8) infection Fully differentiated MTEC cells were infected with PR8 (moi: 0.3) or mock infected and RNA was collected at 24 hours post infection

2013-08-30 | E-GEOD-43707 | biostudies-arrayexpress

Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC), from both wild-type and MAVS-/- mice

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Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

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Environmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [Affymetrix]

Project description:Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activating ligands reduced inflammation in the lesional skin of psoriasis patients, whereas AhR antagonists upregulated inflammation. Similarly, AhR signaling via the endogenous FICZ ligand reduced the inflammatory response in the imiquimod-induced model of psoriasis and AhR deficient mice exhibited a substantial exacerbation of the disease, compared to AhR sufficient controls. Non-haematopoietic cells, in particular keratinocytes, were responsible for this hyper-inflammatory response, which involved increased reactivity to IL-1beta and upregulation of AP-1 family members of transcription factors. Thus, our data suggest a critical role for AhR in the regulation of inflammatory responses and open the possibility for novel therapeutic strategies in chronic inflammatory disorders. Total RNA obtained from skin explants taken from AhR heterozygous or knock-out mice treated pericutaneously with imiquimod for 0 and 2d.

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Environmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation

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Expression data from early and late passages of OVDM1 cell line and the original metastatic tumor

Project description:OVDM1, a new ovarian cell line derived from a serous ovarian metastatic adenocarcinoma sample, was established by immortalization with SV40 large-T antigen and hTERT and then characterized Expression microarrays were used for molecular profiling of early and late passages of OVDM1 cell line, as well as the original metastatic tumor. Total RNA was extracted from early and late passages of OVDM1 and from the metastatic tumor for hybridization on Affymetrix microarrays

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Expression data from chemokine-deficient mus musculus subjected to traumatic brain injury (TBI)

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