Redefinition of Human Androgen Responsive Elements [MNase-Seq, ChIP_seq]

ABSTRACT: The androgen receptor (AR) mediates the action of androgens by binding to androgen-responsive elements (AREs) and subsequently regulating target genes involved in prostate carcinogenesis. The precise locations, true nature, and functional roles of AREs in human prostate cancer are still unknown. Here we redefine AREs by motif-resolution AR chromatin immunoprecipitation-exonuclease (ChIP-exo) assay in human prostate cancer cells and tumors. Surprisingly, we find that, in addition to canonical full-length AREs and half-site-like AREs, a significant portion of the four redefined ARE categories comprises non-canonical full-length AREs. The redefined AREs in enhanced AR binding regions in prostate tumors versus paired non-malignant adjacent tissues regulate a prostate cancer-relevant gene netwo

ORGANISM(S): Homo sapiens

SUBMITTER: Xun Lan 

PROVIDER: E-GEOD-43720 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress