Doxorubicin enhances nucleosome turnover around promoters

ABSTRACT: We use a metabolic labeling strategy for directly measuring nucleosome turnover to examine the effect of doxorubicin on chromatin dynamics in squamous cell carcinoma cell lines derived from genetically defined mice. We find that doxorubicin enhances nucleosome turnover around gene promoters, and turnover correlates with gene expression level. Keywords: Chromatin affinity-purification on microarray 26 CATCH-IT arrays and 8 expression arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Jorja Henikoff 

PROVIDER: E-GEOD-43753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress