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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from exponentially proliferating ovarian cancer cell lines

ABSTRACT: We used microarrays to assess gene expression in proliferating ovarian cancer cell lines Ovarian cancer cell lines were plated and harvested when 50-80% confluent. RNA was extracted and hybridized on Affymetrix microarrays. At least 3 biological repeats were performed for each cell line.

ORGANISM(S): Homo sapiens

SUBMITTER: Karen Sheppard

PROVIDER: E-GEOD-43765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.

Sheppard Karen E KE Cullinane Carleen C Hannan Katherine M KM Wall Meaghan M Chan Joanna J Barber Frances F Foo Jung J Cameron Donald D Neilsen Amelia A Ng Pui P Ellul Jason J Kleinschmidt Margarete M Kinross Kathryn M KM Bowtell David D DD Christensen James G JG Hicks Rodney J RJ Johnstone Ricky W RW McArthur Grant A GA Hannan Ross D RD Phillips Wayne A WA Pearson Richard B RB

European journal of cancer (Oxford, England : 1990) 20130903 18

<h4>Background</h4>Ovarian cancer is the major cause of death from gynaecological malignancy with a 5year survival of only ∼30% due to resistance to platinum and paclitaxel-based first line therapy. Dysregulation of the phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) and RAS/extracellular signal-regulated kinase (ERK) pathways is common in ovarian cancer, providing potential new targets for 2nd line therapy.<h4>Methods</h4>We determined the inhibition of proliferation of an e ...[more]

PMID: 24011934

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