Identification of miRNA differential expression patterns in a new model of acquired letrozole resistance

ABSTRACT: Since differential miRNA expression patterns associated with acquired AI resistance have been poorly investigated, the aim of this study was to delineate the deregulation of miRNA expression associated with letrozole response failure in a new model of letrozole resistance. For this purpose, we generated and characterized a novel cellular model of acquired resistance to letrozole (Res-Let cells) and performed microarray experiments to identify miRNAs whose expression was either deregulated between control (MCF-7aro) and resistant cells (Res-Let) or differentially expressed between the two cell lines under letrozole exposure. With the aim to select relevant miRNAs, two independent cell culture replicates were performed for each experimental condition. MCF-7aro and Res-Let cells were grown in

ORGANISM(S): Homo sapiens

SUBMITTER: Julie Vendrell 

PROVIDER: E-GEOD-43766 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress