Sequential waves of gene expression in patients with clinically defined Dengue illnesses reveal subtle disease phases and predict disease severity.

ABSTRACT: Background: Dengue virus (DENV) infection often leads to acute illness lasting 2-7 days with severity ranging from dengue fever (DF) to hemorrhagic fever (DHF) and fatal dengue shock syndrome (DSS). The dynamic changes of host responses on the gene transcription level that accompany DENV infection and differences between DF and DHF cases have been poorly understood, particularly for South American population. Methodology/Principal Findings: Supported by a longitudinal active surveillance program for dengue transmission in Maracay, Venezuela, we conducted a prospective study to investigate host responses in dengue patients. Blood specimens and clinical information were collected on a daily basis from febrile cases confirmed with DENV infection from their first day of enrollment to early d

ORGANISM(S): Homo sapiens

SUBMITTER: peifang sun 

PROVIDER: E-GEOD-43777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress