Campylobacter jejuni Cj1000 regulon

ABSTRACT: Transcriptional regulation mediates adaptation of pathogens to environmental stimuli and is important for host colonisation. The Campylobacter jejuni genome sequence reveals a surprisingly small set of regulators, mostly of unknown function, suggesting an intricate regulatory network. Interestingly, C. jejuni lacks the homologues of ubiquitous regulators involved in stress response found in many other Gram-negative bacteria. Nonetheless, cj1000 is predicted to code for the sole LysR-type regulator in the C. jejuni genome, and thus may be involved in major adaptation pathways. A cj1000 mutant strain was constructed and found to be attenuated in its ability to colonise 1-day old chicks. Complementation of cj1000 mutation restored the colonisation ability to that of wild type levels. The muta

ORGANISM(S): Campylobacter jejuni

SUBMITTER: Alain Stintzi 

PROVIDER: E-GEOD-43792 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress