Repeated observation of breast tumor subtypes in independent gene expression data sets

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE4335: Norway/Stanford Breast Tumors GSE4336: Breast Tumors Abstract: Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we have refined the previously defined subtypes of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534 "intrinsic" genes and shown to subdivide into one basal-like, one ERBB2-overexpressing, two luminal-like, and one normal breast tissue-like subgroup. The genes used for classification were selected based on their similar expression levels be

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-GEOD-4382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress